The meeting came amid concerns over the unexplained incidents that have harmed the staff some with ailments as serious as traumatic brain injury. The ailments may have been caused by a sonic wave machine or other high-pitched sound bombardments.
"The conversation was firm and frank and reflected the United States' profound concern for the safety and security of its diplomatic personnel," the State Department Spokesperson, Heather Nauert said after the meeting between the two diplomats in Washington DC.
Earlier in the day, Nauert told reporters that as many as 21 Americans have been medically confirmed as having been affected by incidents in Cuba which began in late 2016.
After the meeting, Cuban Foreign Minister Bruno Rodriguez said Havana has been conducting its own investigation into the incidents, on orders from "the top level of the Cuban government," the Washington Post reported.
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But it said Cuba so far had found no evidence pointing to the cause or origin of the health disorders that have affected Americans connected to the embassy, the report said.
"It would be regrettable that a matter of this nature is politicised and that hasty decisions not supported by conclusive evidence and investigation results are taken," Rodriguez said.