"Welcome to the 71st Annual Tina Fey and Amy Poehler's Lee Daniel's The Butler Golden Globe Awards!," their opening monologue said.
Fey and Poehler, who are old friends and worked together on Saturday Night Live for many years, were in no mood to spare any actor including the awards organiser Hollywood Foreign Press.
"We are very happy to be back. We are hosting the Golden Globes for our second time. Because this is Hollywood, and if something kind of works, they'll just keep doing it until everybody hates it!," Fey said alluding to their second year as hosts.
"Woody Allen is the recipient of this year's Cecil B DeMille Award, just a few years after Martin Scorsese won it. I assume the award is for tiniest man who wears glasses," Poehler said.
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'American Hustle' was the big winner at the awards including best picture in a comedy or musical, best actress for Amy Adams and best supporting gong for Jennifer Lawrence but it was Bradley Cooper's perm that got the vote from Tina.
Streep, who was in the audience, was also targetted by the duo as they joked about her role in 'August: Osage County'.
"Meryl Streep is so brilliant in August: Osage County, proving that there are still great parts in Hollywood for Meryl Streeps over 60," Fey said to a laughing Streep.
Sandra Bullock-George Clooney's space disaster drama 'Gravity' won the best director award for its helmer Alfonso Cuaron but it did not survive Fey's humour.
Poehler managed to call out to Matt Damon and remind him that he was in a big company.
"Matt Damon is here, for Behind the Candelabra. Matt, on any other night, in any other room, you would be a big deal. But tonight, and don't take this the wrong way, you're basically a garbage person," Poehler said.
"Matthew McConaughey did amazing work this year. For his role in Dallas Buyers Club, he lost 45 pounds. Or what actresses call being in a movie," Fey observed.