Police said all steps have been taken including deployment of adequate personnel across the state to ensure maintenance of law and order.
DMK, Congress, CPI(M), CPI, VCK, IUML and a host of trade unions affiliated to the opposition parties, farmers bodies, the film fraternity and other organisations including a lorry operators association have pledged support to the general shutdown.
Also, associations of local vegetable markets, groceries, several trade unions of auto-drivers are among those who support the bandh.
Local, long-distance buses of the state-run transport corporations and trains will ply as usual and essential services including milk and electricity supply will be normal, they said.
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Ruling AIADMK (Amma) and the BJP have hit out at the bandh call terming it politically motivated.
On April 16, a meeting of parties including Congress, CPI(M), CPI, VCK, IUML chaired by DMK working president M K Stalin gave the bandh call.
Other demands include remunerative price for paddy, sugarcane, immediate disbursal of cane arrears to the farmers, increasing the water level of Mullaperiyar dam to 152 ft and cancelling Methane and Hydrocarbon projects.
Waiver of crop loans given by nationalised banks, adequate monetary compensation to farmers affected by drought are among the demands of a group of ryots who protested in Delhi and in other parts of Tamil Nadu.