The 62-year-old will lend his voice for an upcoming episode, which will be on survivalism movement, involving people making preparations for potential global disasters, reported Contactmusic.
Waits will introduce the main character Homer Simpson to a group of preppers, who lay down plans for such events.
"We did a lot of research into the 'prepper' phenomenon, where people are convinced that some horrible catastrophe - like an electromagnetic pulse - is going to occur, and that people will have to survive without the grid," said Al Jean, executive producer of the show.