The event raised funds for Nancy Davis' non-profit organisation that she founded in 1993 after she was diagnosed with multiple sclerosis, said The Hollywood Reporter.
The star-studded benefit featured performances from artistes Rita Ora and Ne-Yo.
"When I was diagnosed, there was no options and they told you to go home and go to bed. Today there are eleven drugs on the market. Many more are coming through the pipeline for different treatments, and we're so thrilled and excited that here we are today," Davis said.
Hilfiger's son, Richard, and daughter, Ally Hilfiger, presented the Medal of Hope to the fashion designer, who addressed his personal connection to the disease.
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"I accept this award on behalf of my sister who has had MS for over 25 years. She's in a wheelchair. She is great in spirit but she suffers and watched this over the years," Hilfiger said.
The designer has significantly donated to finding a cure for MS, but he expressed that Davis and her Center Without Walls program deserves the real credit for making advances in the treatment of MS.