Adults who drink excessively were found to have less nitric oxide in their exhaled breath than adults who do not drink.
The finding is significant because nitric oxide helps protect against certain harmful bacteria, researchers said.
"Alcohol appears to disrupt the healthy balance in the lung," said lead author Majid Afshar, from Loyola University Chicago Stritch School of Medicine in the US.
This is the first study to report such a link between excessive alcohol consumption and nitric oxide.
Researchers analysed the molecular, cellular and physiological responses to acute, binge and chronic alcohol consumption.
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Excessive drinkers were defined as heavy drinkers (more than one drink per day on average for women and more than two drinks per day for men) and people who binge drink at least once per month (four or more drinks per occasion for women and five or more drinks for men).
In the sample population researchers examined, 26.9 per cent of the participants were excessive drinkers.
Nitric oxide is a colorless gas produced by the body during respiration. Nitric oxide and similar molecules play an important role in killing bacteria that cause respiratory infections.
In an asthma patient, the amount of exhaled nitric oxide in a breath test provides a good indication of how well the patient's medication is working.
Excessive alcohol consumption might complicate the results of such tests.
"Accounting for alcohol use in the interpretation of [exhaled nitric oxide] levels should be an additional consideration, and further investigations are warranted to explore the complex interaction between alcohol and nitric oxide in the airways," researchers said.
The study was published in the journal Chest.