The woman in Wisconsin, who had undergone knee-replacement surgery five years earlier, landed at the hospital emergency room with chills and a painful, swollen right knee, doctors said in a report of her case published in the journal BMJ Case Reports.
Doctors found that her knee was infected with Streptococcus gordonii, a bacterium that is typically found in the mouth.
The woman mentioned to her doctors that she had voluntarily started a vigorous dental flossing regimen, with bleeding from her gums as a result.
"This bacteria lives in the mouth, [but doctors] happened to find it in a place where we don't typically find it, which is the knee joint," said Dr Ala Dababneh, an infectious diseases doctor at the Mayo Clinic in Minnesota and a co-author of the report.
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The doctors operated upon the woman's knee, washing out as much of the bacteria as possible, 'LiveScience' reported.
The woman was able to keep her original knee replacement and has since recovered, but must keep taking the antibiotics for as long as she keeps the prosthesis, Dababneh said.
"[But] it's a rare event. I don't want people to worry that just flossing is going to cause them an infection in their prosthetic joint," Dababneh said.
Doctors in the report said that it's rare to find an S gordonii infection on a prosthetic; just about 2 per cent of late-onset prosthetic joint infections involve the bacterial group streptococci.
Most infections on prosthetic devices (57 per cent) are related to the bacteria Staphylococcus aureus and Staphylococcus epidermidis, which are frequently found on the skin or respiratory tract.