The bag belonged to an Indore-based trader, Jayant Jain who after keeping the bag under the seat in the bus, got down for a cup of tea, a police official said.
According to eyewitnesses, the bag was taken away by two youths after stuffing it in a sack. They left the spot in a car.
Sub Divisional Officer of Police (SDOP) Vinod Shrivastava said the theft is being investigated and roads in all directions were cordoned off for carrying out searching.