The White House said one person was killed, and local officials said others were injured in yesterday's incident.
Lawmakers said the fatality appeared to be someone in the truck. One lawmaker aboard the train, Tom Cole, a Republican from Oklahoma, said the vehicle had been ripped in half. He said he saw a person wrapped in a tarp and said emergency workers appeared to be "putting a body away."
Cole said he felt "a tremendous jolt" when the accident occurred, nearly two hours after the train left Washington headed to the Greenbrier resort in White Sulphur Springs, West Virginia.
Alex Prevost, a University of Virginia health system spokesman, said it had received three patients and two more were on the way. He could not confirm a fatality.
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Albemarle County police spokeswoman Madeline Curott also would not confirm a fatality but said three people on the truck were seriously injured.
Minnesota Representative Jason Lewis' staff members tweeted that the first-term congressman was among those taken to the hospital. The tweet from Lewis' account said he was being checked for a concussion because of the impact.
Cole said the train stopped quickly after impact. He said several GOP lawmakers who are doctors got off the train to assist, including Representative Brad Wenstrup, R-Ohio, who was also at last June's shooting of Republicans at a baseball practice in nearby Alexandria, Virginia, and treated some of the victims.
Another lawmaker, Representative Kevin Cramer, R-N.D., was conducting a live interview with a local radio station when the accident occurred.
Authorities have not detailed the sequence of events. Other doctor-lawmakers who helped included Reps. Michael Burgess, of Texas, Phil Roe of Tennessee, Larry Bucshon of Indiana and Roger Marshall of Kansas; and Sen. Bill Cassidy of Louisiana.
Cassidy later tweeted that there were three people on the truck and "one is dead."
House Speaker Paul Ryan of Wisconsin was on the train and was unhurt, aides said.
"There is one confirmed fatality and one serious injury," but no injuries to lawmakers or their staffs, she said.
"Our thoughts and prayers are with everyone that has been affected by this incident," Sanders said.
Representative James Comer of Kentucky said about 100 Republican lawmakers were on the train when the crash occurred, which made him jump out of his seat.
"I looked out the side of the window and then I could see a truck, just in pieces out the side of the window," Comer said. "It was a garbage truck that was apparently, I would assume, trying to cross the tracks."
A GOP aide said the train seemed partially derailed.