Trott, who made a brief comeback after returning home following England's opening loss in a 5-0 Ashes reverse in Australia, announced he was bowing out of both Warwickshire and international duty with immediate effect after suffering a relapse in his condition.
South Africa-born Trott came under fire from the likes of former England captain Michael Vaughan when, during a television interview last month, he said he'd been suffering from "burn out".
But Somerset batsman Trescothick was more sympathetic, having pulled out of England's 2006/07 Ashes tour when he too suffered with a stress-related illness.
"I've spoken to him on a few occasions just to try and help, as someone who has been through exactly the same situation, coming back from Australia," Trescothick said Saturday.
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But Trescothick was adamant Trott had meant no offence towards the mentally ill.
"I didn't have a problem with what he said. People picked up on words and it was taken at the wrong time and the wrong moment," said Trescothick.
"We have to allow him the fact that he's the one going through it, he's going through tough times and he has to work it out himself.