The incident took place last night, near a gas agency in Chandpur police station area.
The truck carrying soaps and detergents of an FMCG company, had arrived from Saharanpur and was stationed near the agency when some unidentified persons attacked the duo, police said.
They tied the driver, identified as Meharban, and the conductor Najim, and looted the entire goods worth Rs 3 lakh and then escaped.
No arrest has been made so far and police is on the look out for them.