"We need to turn this painful awakening into a political wake-up call," Moscovici said in an address at Harvard University, adding that discontented voters on both sides of the Atlantic now distrusted the state institutions built to serve them.
Moscovici said that income inequality and flagging economic growth, terrorist attacks and war in the Middle East had undermined the value of Europe in many voters' eyes, while the gulf separating them from political elites had widened.
"These people consider themselves the losers of globalisation. We should not misunderstand the meaning of their vote. Even if driven by anger, it is completely rational."
Moscovici called for a "more political Europe" which could counter what he called populist narratives.
"Europe needs to be able to prove to all parts of its population, who are feeling the effects of globalization in very different ways depending on where they live and what their skills are, that it is still able to offer them protection," he said.
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