Less than two months before the first state-wide votes to determine the parties' nominees, Trump was the undisputed Republican leader with 27 per cent, while his closest challenger for months, retired neurosurgeon Ben Carson, has faded to third place, according to the Quinnipiac University survey.
Freshman Senator Marco Rubio of Florida has surged into second with 17 per cent, while Carson is tied for third with Senator Ted Cruz of Texas at 16 per cent. Former Florida governor Jeb Bush languishes in fifth place with five percent, while no other candidate is above three per cent.
Trump has faced fierce criticism for several remarks he has made in recent weeks, including saying "thousands" of Muslims in New Jersey cheered when the World Trade Center collapsed in the 9/11 attacks of 2001, a claim that has been widely debunked.
"It doesn't seem to matter what he says or who he offends, whether the facts are contested or the 'political correctness' is challenged, Donald Trump seems to be wearing Kevlar," Quinnipiac assistant poll director Tim Malloy said in a news release detailing the results.
More From This Section
On the Democratic side, Clinton has risen to 60 per cent support, double the backing of her nearest rival, Senator Bernie Sanders of Vermont, at 30 percent, according to Quinnipiac.
Former Maryland governor Martin O'Malley registers just two percent in the much smaller Democratic field.
Clinton, bolstered by Vice President Joe Biden's decision not to seek the nomination, has appeared more confident on the campaign trail.
Sanders, a self-described democratic socialist, has sought to seduce voters on the left, but his campaign, which soared in the summer, appears to have come down to Earth and is plodding along with little gain against Clinton.