"He didn't want to have even the perception of a conflict of interest with drug companies or, frankly, insurance companies," Trump told Fox News Radio in an interview today, shortly after breaking the news on Twitter.
The announcement follows reports by The Washington Post and CBS News, which detailed the Pennsylvania lawmaker's involvement in crafting a 2016 law, signed by President Barack Obama, that weakened the Drug Enforcement Administration's authority to curb opioid distribution.
Interviewed by Fox News Radio's Brian Kilmeade, Trump said Marino "felt compelled" to step down from the job.
"He feels very strongly about the opioid problem and the drug problem and Tom Marino said, 'Look, I'll take a pass,'" Trump added. Trump did not say when he and the congressman spoke. Marino could not immediately be reached today for comment.
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"Tom is a fine man and a great Congressman!" he added.
Trump had told reporters during a news conference in the White House Rose Garden yesterday that he would look "very closely" at the reports about Marino, adding: "If I think it's 1 percent negative to doing what we want to do, I will make a change," he said.
Democrats had called on Trump to withdraw the nomination, and hailed the news, with Senate Minority Leader Chuck Schumer calling Marino's decision the "right decision."
Manchin had scolded the Obama administration for failing to "sound the alarm on how harmful that bill would be for our efforts to effectively fight the opioid epidemic," which kills an estimated 142 people a day nationwide.
In a letter to Trump, Manchin called the opioid crisis "the biggest public health crisis since HIV/AIDS," and said, "we need someone leading the White House Office of National Drug Control Policy who believes we must protect our people, not the pharmaceutical industry."
Sen. Orrin Hatch, R-Utah, the bill's lead Senate sponsor, defended the measure yesterday, calling allegations that he or Marino "conspired" with drug companies "utterly ridiculous." Hatch, a 40-year veteran of the Senate, said he was "no patsy" of the drug industry.
"Let's not pretend that DEA, both houses of Congress and the Obama White House all somehow wilted under Representative Marino's nefarious influences," Hatch said.
Sen. Claire McCaskill, D-Mo., said yesterday she will introduce legislation to repeal the 2016 law.
A White House commission convened by Trump and led by New Jersey Gov. Chris Christie has called on Trump to declare a national emergency to help deal with the growing opioid crisis. An initial report from the commission in July noted that the approximate 142 deaths each day from drug overdoses mean the death toll is "equal to September 11th every three weeks."