In an Oval Office meeting, Trump said that el-Sissi has done a "fantastic job" and declared his support for Egypt and the Egyptian people.
Trump noted that the US plans to build its military to "possibly" its highest levels as it looks to fight the Islamic State group and lend support to its allies.
The two leaders are also expected to discuss military and economic aid for the country.
Trump has repeatedly mentioned Egypt as a critical Muslim-majority ally in the fight against extremists like the Islamic State group.
The White House welcome comes after a tense relationship between Egypt's leader and the previous administration. Former President Barack Obama never invited el-Sissi to the White House and allowed his administration to repeatedly admonish his government over its human rights record. Obama also briefly suspended some US military aid.