"I think that being a loose cannon means saying that other nations should go ahead and acquire nuclear weapons for themselves, when that is the last thing we need in the world today," Clinton told CBS News in an interview when asked about her allegations early this week that Trump is a loose cannon.
"Being a loose cannon is saying we should pull out of NATO, the strongest military alliance in the history of the world and something that we really need to modernise, but not abandon," she said.
Clinton said the Republicans themselves are raising questions about their presumptive nominee.
"When you have former presidents, when you have high- ranking Republican officials in Congress raising questions about their nominee, I don't think it's personal, so much as rooted in their respect for the office and their deep concern about what kind of leader he would be," she said.
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The former Secretary of State alleged that Trump has slogans and not policies.
"When he says women should be punished for having abortions, what does that mean, and how would he go about that, or rounding up 11 million, 12 million people, which he again repeated, which would entail the most comprehensive police and military action inside our borders that is imaginable?" she questioned.
Clinton reiterated that she would not indulge in personal mudslinging.
"I don't really feel like I'm running against Donald Trump. I feel like I'm running for my vision of what our country can be and to knock down all the barriers that stand in the way of Americans getting ahead," she said.
Trump, she alleged, doesn't understand that running the government is not the same as making real estate deals.
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"My opponent chose to make many of his products overseas. He buys cheap Chinese steel and aluminum instead of good American steel, made by American steel workers. He's gone all over this country, and he's gone all over Michigan talking about how he's gonna really get more jobs and he's going to bring back what used to be there.
She alleged that Trump's economic plan has cut trillions of dollars in taxes from millionaires, billionaires and corporations.
"That is trickle-down economics on steroids. I profoundly disagree. I think the way you build an economy is from the middle out and the bottom up, not from the top down," she added.
"When you think about it, Donald hasn't paid anything for 20 years. He's paid zero to support our military, our vets, Pell grants for students here at Grand Valley, our highways - and I am still pondering, I am just pondering how anybody can lose a billion dollars in one year," Clinton said.
"We can't afford that. We need to keep building. We have recovered from the worst financial crash since the Great Depression but we're not where we need to be yet.
"The last thing we need is a failed economic policy coming back in and pushing us back down. And depriving people of the jobs that we want to create," Clinton said.