The billionaire Republican candidate for president, who has denounced Clinton's USD 42 million war chest as "blood money," sharpened his attacks on the polarizing Democratic nominee after disastrous headlines have fueled speculation that his controversial campaign is unravelling.
"Hillary Clinton may be the most corrupt person ever to seek the presidency," he said in a speech at Trump SoHo, his five-star hotel in Manhattan to shouts of "Trump, Trump, Trump" from supporters.
Trump attacked Clinton as a "world-class liar" who had "perfected the politics of personal profit and theft" and lacked the judgment to be America's first woman commander-in-chief.
"She ran the State Department like her own personal hedge fund -- doing favours for repressive regimes, and many others, in exchange for cash," he alleged of her tenure as America's top diplomat.
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"In just four years, secretary Clinton managed to almost single-handedly destabilise the entire Middle East," he added, calling the Islamic State extremist group a threat because of her decisions.
On economics, he assaulted her support for trade deals, saying they had wrought "total devastation" for working Americans and cost the country nearly a third of its manufacturing jobs.
America's trade deficit with China had soared by 40 percent while she was secretary of state, he said: "Hillary Clinton gave China millions of jobs and in exchange Hillary Clinton got rich."
He also claimed that her family's Clinton Foundation had taken millions from countries in the Middle East that abuse women and members of the LGBT community.