Irma was expected to strike the Florida Keys at daybreak today.
Trump called it a "storm of enormous destructive power" and asked "everyone in the storm path to heed all instructions, get out of its way."
"Property is replaceable but lives are not and safety has to come first," Trump said at a Cabinet meeting at the Maryland retreat, where he was spending the weekend with his wife, first lady Melania Trump. "Don't worry about it. Just get out of its way." Trump shared a brief video of his remarks on Twitter.
Trump said the US was grieving for those who were killed by Irma even before she reached the US mainland. The storm left more than 20 people dead in the Caribbean. He said the administration is monitoring the situation "around the clock" and is in "constant communications" with governors and other officials from the affected areas.
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"We've never seen anything like this," he said, pledging as he did after Hurricane Harvey that recovery and rebuilding will happen quickly.
Elaine Duke, the acting head of the Department of Homeland Security, was scheduled yesterday to brief Trump and the rest of the team on the storms.
In between storm updates, Trump spent part of his fourth Cabinet meeting discussing administration priorities and how to advance them during what's left of his first year in office.
"I think now, with what's happened with the hurricane, I'm going to ask for a speedup. I wanted a speedup anyway, but now we need it even more so," he said in a longer video of the meeting that was released by the White House.
North Korea was also on the agenda. Trump said the Cabinet would discuss North Korea's "latest provocative and destabilizing actions" and "the steps the United States will take to keep our people safe and, frankly, to keep the people of the world safe in this case."
Trump sided with Democrats this week to raise the US borrowing limit and keep the government operating through early December in a bid to speed federal assistance to hurricane victims. Congress acted quickly to pass the USD 15.3 billion deal and send it to Trump, who signed it Friday after he arrived at the Maryland retreat.
The agreement allowed Trump to taste victory after months of legislative setbacks and whet his appetite for more wins. In addition to overhauling the tax code, the president also wants new spending to upgrade roads, bridges and other infrastructure.
The president and Mrs. Trump invited members of the Cabinet and their spouses to Camp David for the weekend, the White House said. It marked Trump's fourth visit to the retreat. He met there in August with members of his national security team, but yesterday was the first time Trump had entertained the entire Cabinet there, including Defense Secretary Jim Mattis, who turned 67 on Friday.
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