The nuclear power station, in Akkuyu in Mersin province on the shores of the Mediterranean is being built, like Iran's first nuclear power plant, by Russia's nuclear agency Rosatom.
"Development cannot happen in a country without nuclear energy," said Turkish Energy Minister Taner Yildiz at a ceremony attended by the head of Rosatom, Sergei Kiriyenko and other top officials.
It is the first of three nuclear power plants Turkey currently plans to build to reduce its dependence on importing energy from exporters like Russia and Iran.
"If we had built this power station 10 years ago, we would have saved USD 14 billion in natural gas purchases," said Yildiz.
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Yildiz and Kiriyenko were to lay the foundation stone for the construction of the power station, which is expected to be completed by 2020 and will have four power units with a capacity of 1200 MW each.
The Turkish authorities have swatted away concerns that the Akkuyu facility lies in a seismic zone, saying it can resist quakes registering up to nine on the Richter scale.
Environmental campaign group Greenpeace in January lodged a complaint in court against the awarding of an environmental impact licence to the plant and says it should not be built.
"Turkey is not ready to build nuclear reactors - the country is still missing the key pieces of necessary legislation," Jan Beranek, the director of Greenpeace Mediterranean, told AFP, saying that the seismic assessment had been "totally inadequate".
The launch of the power plant comes two weeks after Turkey suffered its most serious nationwide power cut in 16 years which exposed the shortcomings of its energy system.