Police said the gunmen fired at least six shots at the Digital Satellite News Gathering (DSNG) van of the Samaa TV channel in the Liaquatabad area of Karachi and then managed to flee from the scene.
However, no one was injured in the attack.
"The crew was not present in the parked van at that time so there was no loss of life or injuries," police official said.
Sindh Home Minister Sohail Anwar Khan Sial said police has been ordered to step up investigations as this was the second attack on a DSNG van of a television channel this month.
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The incident revived bitter memories of another attack earlier this month when unidentified men opened fire on a DSNG van of Geo television network in Bahadurabad area killing a technical engineer and injuring another.
A senior journalist Aftab Alam, who had previously worked for Geo News and Samaa, was also gunned down by unknown assailants near his home in North Karachi last week.
Last year three employees of the Express channel were killed when gunmen opened fire on their DSNG in the Nazimabad area.