Researchers from the University of Surrey in the UK examined 18,000 tweets posted by the three main campaign groups, 'Stronger In', 'Vote Leave' and 'Leave.EU'.
'Vote Leave' focused on economic arguments against the European Union, while 'Leave.EU' highlighted immigration- related issues.
"The outcome of the Brexit vote on June 22, 2016 would not have been as shocking had more attention been paid to what was happening on Twitter," said Simon Usherwood from the University of Surrey.
They found that the Remain campaign was marginally more likely to make negative comments about its opponents.
Also Read
This confused approach is further reinforced when examining the language used in the tweets.
The most commonly used word used in Stronger In's campaign was 'leaving', well in excess of its use by either Leave group.
Similarly the term 'Brexit' was mentioned more by Stronger In than the official Leave campaign (Vote Leave).
The examination of Twitter also showed that Stronger In was disadvantaged by the then UK Prime Minister David Cameron's decision to try and avoid becoming the central figure of the campaign.
While the official Remain campaign rarely mentioned him, both Leave campaigns made much of his words and actions, calling into question his competence and ability and reminding voters that a Leave vote would also hurt his government.
The Leave groups were able to capitalise on an established social media network of anti-EU campaigners helping to publicise its messages to a wider audience, which undoubtedly disadvantaged Stronger In, researchers said.
For example, on the polling day Leave.EU had nearly 50,000 more Twitter followers than Stronger In, while Vote Leave had 20,000 more.
Although the Leave campaign had a significant advantage in being able to mobilise an already extensive social media network, Stronger In's failure to build as extensive an online following showcases the shortcomings in attracting new followers and successfully spreading its message on Twitter.
Disclaimer: No Business Standard Journalist was involved in creation of this content