The company, however, did not disclose the number of people being handed pink slips.
When contacted, Twitter in an emailed statement said: "As part of our normal business review, we have decided to stop the global engineering work at the Bengaluru development centre. We thank the impacted individuals for their valuable contributions and are doing as much as we can to provide them a respectful exit from our company."
The company "remains committed to India as a strategic market for users, partners and advertisers," it added.
Last year, Twitter had acquired Bengaluru-based mobile marketing and analytics company ZipDial Mobile Solutions, its first acquisition in India.
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The move paved the way for the US-based company to set up the engineering centre in Bengaluru.
Twitter had not disclosed financial details of the ZipDial deal, but reports suggested the monetary value was between USD 30-40 million (between Rs 185 crore-Rs 247 crore).
It said both its second-quarter performance and third-quarter outlook reflect "a continuation of the trends discussed last quarter with less overall advertiser demand than expected."
It added that its "brand business remains strong in absolute terms, but there are some new challenges that we're now tackling head-on.