Shares sank more than 12 percent to close at USD 16.41 as investor hopes faded for a revival of growth at the messaging platform, which has lagged behind its rivals in the fast-moving social media sector.
Twitter reported a net loss in the fourth quarter of USD 167 million, after a USD 90 million deficit in the corresponding period a year ago.
Revenue in the quarter rose a modest one percent to USD 717 million.
Advertising revenue, which makes up the lion's share of Twitter's receipts, was down slightly from a year ago at $638 million. Its revenue from the United States was down five percent at $440 million.
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"The whole world is watching Twitter," Dorsey told a conference call.
"While we may not be meeting everyone's growth expectations, there's one thing that continues to grow and outpace our peers: Twitter's influence and impact."
He added that Twitter "carries some of the most important commentary and conversations," and is used to mobilize people into action.
But some analysts say Twitter is moving far too slow in the rapidly evolving social media space.
Jan Dawson at Jackdaw Research said Twitter has been trying to get more users and improved engagement but that "some of this stuff has been in the works for over two years, and Twitter still doesn't seem to be making meaningful progress."
"Twitter's big competitors for direct response advertising -- notably Facebook and Google -- are just way better at this stuff than they are, and Twitter simply hasn't made anywhere near enough progress here over the last few years. As a result, Twitter is enormously susceptible to competitive threats.
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