The attack comes just a day after Maoists blew off an anti-landmine vehicle killing a CRPF trooper in the same district.
A Tata-407 vehicle was blown up killing two CoBRA commandos on the spot, senior officials said.
The commandos, identified as constable K P Singh and Mukul Burman, were carrying rations for a CRPF camp nearby when the blast occurred.
Senior officials said the blast took place near Basuguda, where joint security forces had carried out a controversial encounter last month.