The blast late last night, which police say is not linked to terrorism, collapsed or severely damaged several buildings in the Paardenmarkt area of central Antwerp, a Dutch-speaking city in northern Belgium.
"Police confirm two more victims found under the rubble, both deceased. The victims have not yet been identified," Antwerp police said on Twitter.
Several people were pulled alive from the rubble on Monday night.
"Research into the cause of the explosion at Paardenmarkt continues," it added.
Police said the explosion was not related to terrorism, while Belgium has been on a high state of alert since 16 people were killed in suicide bombings in the capital Brussels in March 2016.
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