Babu Ram Uniyal and Himalayan Sherpa were arrested from Clement Town area of the city by the Special Task Force following a tip-off, police said.
Two pieces of leopard skin worth Rs 12 lakhs in the international market were seized from their possession, they said.
A case under the Wildlife Protection Act has been registered against the duo at the Clement Town police station, police said.
The arrests come in the wake of complaints that endangered wildlife species were being poached in the Himalayan highlands and their parts smuggled to Nepal and Tibet.
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