The driver of the speeding vehicle, carrying pilgrims to the historic Shiva Dol in Sibsagar from Dhekiajuli in Sonitpur district, lost control and skidded off the road at Badulipukhuri under Teok police station.
The dead have been identified as Madan Mahato and Bhola Mahato.
The injured were admitted to Jorhat Medical College Hospital where the condition of nine persons was stated to be "very critical", the police said.