The mishap occurred apparently after the driver of the van, carrying at least ten persons, lost his control over the vehicle which was headed towards Srikakulam, said Inspector A S Chakravarthi of Bhogapuram police station.
The deceased are identified as A Malleswari (38) and P. Manmadha Rao (45).
The injured were admitted to King Geroge Hospital in the city and their condition is stated to be stable, he said.