The incident happened when all the four passengers were returning home in an auto today morning, Inspector DP Shukla said.
The driver of the three-wheeler lost control of the vehicle and rammed into a motionless truck near Butt village under Kotwali Robertsganj police station area, he added.
45-year-old Sawar Tara and 35-year-old Kamlawati, died on the spot while the two injured were taken to a nearby hospital.
The bodies have been sent for post mortem examination, Shukla said adding that the investigation is on in the matter.