The ATC issued black warrants against Attaullah alias Qasim and Mohammad Azam alias Sharif, who were sentenced to death in July, 2004 for killing Dr Ali Raza Peerani.
The superintendent of the Karachi central prison informed the ATC through a letter that the appeals of the convicts had already been dismissed by the higher and superior judiciary and a review petition had also recently been turned down by the apex court, Dawn reported.
The mercy petition of the death-row prisoners was rejected by the president.
Peerani was killed in 2001 by armed motorcyclists in a targeted attack on sectarian grounds when he came out of his clinic in Soldier Bazaar and was about to leave in his car. The wounded doctor was rushed to a hospital where doctors pronounced him dead on arrival.
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The death sentence on the duo was stayed after the Pakistan Peoples Party government placed a moratorium on executions after coming into power in 2008.
There are over 8,000 death row prisoners in the country.