"The MINUSCA (peacekeeping mission) regrets to announce the deaths of two more blue helmets yesterday afternoon in Bangassou," a town 700 kilometres (430 miles) east of the capital Bangui, the peacekeeping force said in a statement.
The Moroccan peacekeepers "were killed in an ambush by suspected anti-Balaka fighters, while another peacekeepers was lightly injured," MINUSCA said in its statement.
The country is struggling to emerge from a civil war that erupted in 2013 following the overthrow of former president Francois Bozize, a Christian, by Muslim rebels from the Seleka coalition.
A similar ambush in Bangassou on Sunday left another Moroccan UN peacekeeper dead.
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On Friday, a patrol of peacekeepers was shot at and one of the attackers killed, a MINUSCA spokesman told AFP, again blaming pro-Christian militias.
Former colonial power France intervened in 2013 to stop violent Christian-Muslim clashes and formally ended its peacekeeping mission only last month, hailing it a success despite fresh outbreaks of violence.
That leaves mainly the UN's 12,500-strong MINUSCA peacekeeping mission to protect civilians from armed groups.
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