Scottish and United States officials agree "there is a proper basis in law... To treat two Libyans as suspects in the continuing investigation into the bombing of flight Pan Am 103 over Lockerbie," according to a statement released by prosecutors.
"The two individuals are suspected of involvement, along with Abdelbaset Ali Mohmed Al Megrahi," it added.
Megrahi was found guilty of the bombing in 2001. He is the only person ever convicted of the crime.
"The Lord Advocate and the US Attorney General are seeking the assistance of the Libyan judicial authorities for Scottish police officers and the FBI to interview the two named suspects in Tripoli," the statement said.
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The Scottish government released Megrahi on compassionate grounds in 2009 after he was diagnosed with terminal cancer. He died in Libya in 2012 still protesting his innocence.
Libya admitted responsibility for the bombing in 2003 and the regime of slain dictator Moamer Kadhafi eventually paid USD 2.7 billion (2.4 billion euros) in compensation to victims' families as part of a raft of measures aimed at a rapprochement with the West.