Saina, the London Olympic bronze medallist, had clinched the title in 2011 and 2012 and the Indian will look for a repeat performance when she starts her campaign against a qualifier in the women's singles competition on Wednesday.
Seeded sixth, Saina, who had reached the semifinals last year, is coming into the tournament after crashing out in the quarterfinals of the All England Open in Birmingham, UK last week.
It was at the London Olympics where Saina had faced Yihan last time. The Chinese had retired from the play-off because of a knee injury, thus paving the way for the Indian to win the coveted bronze.
However, Saina holds a rather unimpressive 1-6 record against Yihan and she will have to play out of her skin if she has to cross the last eight stage.
World No. 9 P V Sindhu too will be eager to get over her forgettable All England debut when she plays in the Swiss Open. Her first round opponent Beatriz Corrales of Spain has already withdrawn and the Hyderabadi is likely to sail into the quarterfinals.