"We can confirm that two members of the US embassy in Caracas were injured during an incident early this morning," State Department spokesman Patrick Ventrell told reporters in Washington.
"Medical staff inform us that their injuries are not life-threatening," he added, noting that they were hurt at "some sort of a social spot" but without specifying the venue or nature of their injuries.
US diplomatic sources later confirmed to AFP that the two men were shot yesterday.
"My understanding is that they are other agency personnel, not from the State Department," Ventrell said.
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Venezuelan television channel Globovision reported on its website that the incident took place at the Antonella bar located in a shopping center in the Chacao district of Caracas, after an altercation with other bar patrons.
Bar staff told AFP on condition of anonymity that the venue is indeed a strip club that only admits men over the age of 30, but refused to say anything about the alleged incident involving the US embassy personnel.