The duo was identified as Jyoti and Chandni, both residents of railway station area of Ludhiana.
Police said Jyoti was arrested at a police barricade at Grain market near Bhullarai road last night and 25 gram smack was seized from her possession.
Chandni was arrested at a police barricade at old Banga Octroi post last night and 20 gram smack was seized from her possession, they said.
A case under Sections 21-61-85 of the NDPS Act has been registered against them, police said.