The incident happened when the rapper, 26, was in Hollywood for a concert, reported TMZ.
He filmed the LAPD officers going through his SUV in what seemed to be a parking lot and posted on Snapchat.
"The real crooks," he captioned.
Tyga, who is dating Kylie Jenner, 18, took umbrage at the police action, telling they were "only doing it to get under his skin".
However, law enforcement sources said Tyga has known gang members in his crew and they went to "check things out" after hearing he had a show in Hollywood.