The new rules announced Tuesday target so-called "social media influencers," who parlay their internet fame into advertising products.
Officials said the new rules would help ensure "that media material respects the religious, cultural and social values of the UAE," a federation of seven sheikhdoms on the Arabian Peninsula home to Dubai and Abu Dhabi.
Those affected need to register by the end of June or face 5,000-dirham ($1,360) fines.
The UAE, while liberal in many regards compared to its Middle Eastern neighbors, has strict laws governing expression.