But the 1975 poll, which saw Britain embrace membership of what was then the Common Market, has plenty in common with the current bitter and closely-fought debate.
It also carries lessons for politicians ahead of the June 23 vote on whether to stay in or leave the European Union -- not least that the referendum may not resolve the issue for long.
Labour prime minister Harold Wilson called the referendum on June 5, 1975, as a way of trying to appease the eurosceptic wing of his fractured party, and urged Britons to stay in after securing concessions from Brussels.
For Tim Bale, politics professor at Queen Mary, University of London, the lesson of the past is that a referendum cannot guarantee to put a contentious matter to rest.
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"It will fail utterly to settle the Europe question 'once and for all'," Bale wrote in a blog post.
"As to whether, in a democracy, that kind of never-ending uncertainty is necessarily a bad thing, who knows?" he said.