The Liberal Democrat leader, whose party is the junior partner in Conservative Prime Minister David Cameron's coalition government, said sporting events should be part of a new package of EU sanctions against Moscow.
"You can't have this -- the beautiful game -- marred by the ugly aggression of Russia on the Russian Ukrainian border," Clegg told the Sunday Times newspaper.
"Not only would Vladimir Putin exploit it, I think it would make the rest of the world look so weak and so insincere about our protestations about Vladimir Putin's behaviour if we're not prepared to pull the plug."
Clegg's call echoes that of several German politicians earlier this month, although the idea was quickly rejected by football officials.
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"Sports boycotts have rarely achieved anything, and that's why I think nothing of such a proposal," Theo Zwanziger, a FIFA executive committee member and former president of German football body DFB, told Handelsblatt Online.
The EU and United States accuse rebels of shooting down the Malaysian Airlines plane on July 17, killing all 298 people on board, using a missile from Russia.