Sergei Skripal, 66, and his 33-year-old daughter Yulia,were found collapsed on a shopping centre bench in the town of Salisbury in south-west England on Sunday afternoon and remain in critical condition in hospital.
A police officer who was the first to attend the scene is now in a serious condition in hospital, Metropolitan Police Assistant Commissioner Mark Rowley, head of Counter Terrorism Policing, said today.
The police believe Skripal and his daughter had been "targeted specifically" but have not released further details of the chemical agent used in an apparent attempt to poison them. Some known forms of nerve agents include VX and sarin.
Scientists at Porton Down in Wiltshire have been assisting the investigation, which is being led by Scotland Yard's counter-terrorism command, SO15, along with help from the country's intelligence agencies.
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Earlier today, UK home secretary Amber Rudd chaired a meeting of the government's emergency COBRA committee.
Following the meeting, she indicated that the UK government was trying not to point the finger of blame at the Russian government until more was known.
The Met Police has made a public appeal for information, urging anybody who visited Salisbury town centre on Sunday afternoon or who visited the nearby Zizzi Italian restaurant or the Bishop's Mill pub to comeforward.
"It has not been declared a terrorist incident and we continue to keep an open mind as to what happened," a Met Police statement said.
Skripal's daughter, who had been visiting her father from Russia, had reportedly been out of contact with her relatives in her native country for a few days.
Moscow has described the incident as "tragic" but denied any knowledge of the attack on Skripal and said that it is "always open to cooperation".
"I say to governments around the world that no attempt to take innocent life on UK soil will go unsanctioned or unpunished," Johnson said, later calling the Russian state "in many respects a malign and disruptive force".
Skripal's mysterious illness has invited comparisons with the poisoning in London in 2006 of another Russian spy Alexander Litvinenko. The former KGB agent had been poisoned with the radioactive substance polonium-210 at a central London hotel.