Work and Pensions Secretary Iain Duncan Smith, who has pushed through big changes to the country's welfare system over the past six years, dramatically quit late Friday, accusing the government of targeting the poor for cuts while protecting pensions for the better-off.
"I am passionate about trying to improve the quality of life for those in difficult circumstances," Duncan Smith said Sunday. "Now, I want to do that and I want my party to do that. But I felt that I'm losing my ability to influence that."
The country will decide in a June 23 referendum whether to remain in the 28-nation bloc.
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Duncan Smith's resignation was followed by a series of strikingly barbed and partisan remarks as senior Tories blamed one another for the mess. Pensions Minister Ros Altmann, who worked under Duncan Smith, accused him of wanting "to do maximum damage to the party leadership in order to further his campaign to try to get Britain to leave the EU."
"I fundamentally believe that this is not about Europe," she told the BBC.
Cameron who has staked his political future on getting voters to remain in the EU - is due to report to the House of Commons today about last week's migration summit in Brussels. But the session will likely be dominated by welfare cuts and Europe an issue that has divided the Conservatives since Britain joined the EU in the 1970s.