The bank warned that it now expects GDP to grow 1.9 per cent this year, down from its previous forecast of 2.8 per cent, after an estimated 1.8 per cent growth in 2016.
The pro-Western leadership in Kiev this month halted trade with the Russian-backed insurgents it has been battling since 2014, after rebels seized dozens of Ukrainian-owned businesses on their territory in response to a trade blockade by nationalist protesters.
It also prompted the International Monetary Fund to suspend approval of a new USD 1 billion loan payment for the cash-strapped nation, part of a USD 17.5 billion loan programme first agreed in 2015.
Ukraine's central bank said the blockade would depress metal exports from the eastern regions, while coal imports would increase.
It now expects Ukraine's current account deficit to reach USD 4.3 billion (4.0 billion euros) this year, compared with a previous estimate of USD 3.4 billion.
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