Stephen O'Brien, who took up the job in May, is to hold talks with Syrian officials in Damascus and hopes to meet refugee families in Homs and in the Bekaa Valley in Lebanon, his office said today.
The visit comes amid a new push by the United States and Russia, Syria's ally, along with other key players in the Gulf for renewed peace talks to end the war, now in its fifth year.
O'Brien told the Security Council last month that the crisis was worsening in Syria and that a political solution was more urgent than ever.
An additional 7.6 million are displaced inside the country, uprooting more than half of Syria's pre-war population.
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The humanitarian crisis now tops the UN list of global emergencies, with 12.2 million people in need of aid, including more than 5.6 million children.
O'Brien will travel to Lebanon and Syria from August 14-17 for a first-hand look of the humanitarian impact of the war, in which 240,000 people have died.
O'Brien's job title is Under-Secretary-General for Humanitarian Affairs and Emergency Relief Coordinator.