The appeal came as dozens of people were reportedly killed in Aleppo when regime warplanes dropped barrels packed with explosives on rebel-held districts of the northern city, a focal point of the 33-month war.
The Syrian Observatory for Human Rights said 76 people died yesterday, among them 28 children, in the highest toll for air raids since the war started, while 10 others, including four children, were killed by the same weapons today.
The UN's humanitarian agency OCHA, which launched the appeal for emergency aid, said the funds are needed for 2014, when the number of Syrian refugees in the Middle East will nearly double to exceed four million.
Aid will also be needed for another 9.3 million people inside the war-ravaged country, it said.
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It echoed the assessment of other organisations on the plight of Syrians inside the country and in refugee camps across the Middle East, which have been battered by inclement weather over the past week.
The International Rescue Committee, an NGO, said the price of bread in Syria has soared by 500 percent since March 2011, while the cost of blankets, at $27, is prohibitively high, amounting to " 93 per cent of the average monthly income."