The August 26 report by the UN's World Health Organisation (WHO) said governments should ban the sale of so-called electronic cigarettes to minors, warning they posed a "serious threat" to unborn babies and young people.
The WHO report, to be considered at a global meeting on tobacco control this year, also said e-cigs should be banned from indoor public spaces.
But tobacco specialists, writing in the journal Addiction today, said the report was flawed.
"We were surprised by the negativity of the commissioned review, and found it misleading and not an accurate reflection of available evidence," said Ann McNeill, a professor at the National Addiction Centre at King's College London,
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"E-cigarettes are new and we certainly don't yet have all the answers as to their long-term health impact, but what we do know is that they are much safer than cigarettes, which kill over six million people a year worldwide."
E-cigarettes typically work by vaporising a liquid called propylene glycol, to which nicotine and flavouring have been added. The vapour is inhaled, like traditional cigarettes, but produces vapour instead of smoke.
Supporters of e-cigs say the devices are a safer alternative to traditional tobacco, whose bouquet of toxic chemicals and gases cause cancer, heart disease, strokes and other ailments.
Opponents say the devices have only been around for a few years, and the long-term health impact from inhaling their industrial vapour is unclear.
The WHO report acknowledged that e-cigarettes were "likely to be less toxic" than conventional cigarettes, but more research was needed.
The debate is unfolding as many governments are under pressure to impose regulations on e-cigs. At the moment, the worldwide situation is a patchwork, ranging from complete freedom of sale to bans on sales to minors or of e-cigs that contain nicotine.