Meeting in Poland, the UN's cultural arm voted 12 to three -- with six abstentions -- to give heritage status to Hebron's Old City in the occupied West Bank, which is home to more than 200,000 Palestinians and a few hundred Israeli settlers.
"Just inscribed on @UNESCO #WorldHeritage List & World Heritage in Danger List: Hebron/Al-Khalil Old Town," the organisation said on its official Twitter feed.
Israeli foreign ministry spokesman Emmanuel Nahshon immediately denounced the decision as "a moral blot", saying it denied Jewish history in the city.
Brought by the Palestinians, the resolution declared Hebron's Old City, including areas where settlers live, to be an area of outstanding universal value.
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The resolution was fast-tracked on the basis that the site was under threat, with the Palestinians accusing Israel of an "alarming" number of violations, including vandalism and damage to properties.
The Palestinian foreign ministry called the decision made by UNESCO despite US and Israeli opposition a "success" for Palestinian diplomacy
At various times it has been conquered by Romans, Jews, Crusaders and Mamluks.
The city is home to the imposing Tomb of the Patriarchs, the resting place of key Biblical figures Abraham, Isaac and Jacob and one of the most important religious sites to Muslims and Jews alike.
Hebron is also a stark example of the Israeli-Palestinian conflict.
The few hundred Israelis live closed off in several small settlements most of the world considers illegal, with Palestinians largely banned from entering and using nearby streets.
The Israelis living in Hebron are protected by hundreds of Israeli soldiers, with Palestinians saying the settlements makes their lives impossible.
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