Tuesday sees third-placed Manchester City, six points behind leaders Chelsea but with three games in hand, up against a resurgent Manchester United in an eagerly-anticipated derby at Old Trafford.
Meanwhile Arsenal will try to recover from a 6-0 defeat by Chelsea last weekend -- a humiliating way to mark Arsene Wenger's 1,00th match in charge of the Gunners -- at home to Swansea.
And Wednesday could witness second-placed Liverpool move to within a point of Chelsea, having played the same number of games, if Brendan Rodgers' in-form side defeat relegation-threatened Sunderland at Anfield.
However, they are still 11 points behind fourth-placed Arsenal and now, without injured striker Robin van Persie, face a City side who thrashed bottom-of-the-table Fulham 5-0 last weekend.
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United have won just once against teams in the top nine so far this season, a fact not lost on former Everton manager Moyes.