The organisation asked the Security Council members to act more decisively to protect civilians and prevent millions more people being driven away from their homes.
The Security Council's, and in some cases the UN Secretariat's, ineffective or delayed responses to ongoing conflicts in Syria, South Sudan, Central African Republic and Iraq, have allowed violence to spiral and countless communities to be devastated before meaningful action, if any, is taken, it said.
"While diplomats debate points of order, houses are being burned to the ground and families forced on the run. Long delays and vetoed resolutions are plaguing the supposed 'strong arm' of the UN."
The delayed deployment of UN peacekeepers to the Central African Republic means thousands have already been forced to flee before troops arrive.
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"UN Security Council is spectacularly failing to maintain international peace and security," Amnesty said.
Meanwhile, those countries that have blocked any meaningful action on Syria are contributing the least to the global refugee crisis. Russia and China resettled zero refugees in 2013.
Their donations to the UN appeal for Syria, which secured the largest funds in the organisation's history, are equally pitiful.
Russia contributed 0.3 per cent of those funds in 2013 and 0.1 per cent in 2014, while China contributed 0. 1 per cent in 2013 and 0. 4 per cent in 2014.