Myneni defeated Murugesan 6-3 6-4 in his tournament opener.
Among others, tt was a mixed day for HPTC's Vinod Gowda and qualifier Sagar Manjanna.
Wild card entrant Gowda outplayed local lad Suraj R Prabodh 6-2 6-2 in 53 minutes, while Manjanna lost 3-6 3-6 to Australian rival Zach Itzstein.
Top seed Ti Chen of Chinese Taipei also had no difficulty in disposing another wild card entrant Shahbaaz Khan 6-2 6-2 in just about an hour.
Third seeded Vijayant Malik, the runner up at ITF Mandya Open, also started positively, beating French man Sebastien Boltz 6-3 6-2 in an absorbing baseline tussle in 83 minutes.
Results: Singles First Round Results: Jeevan Nedunchezhiyan (IND) (4) beat Venkat Iyer (IND) 6-0 6-2; Zach Itzstein (AUS) beat Sagar Manjanna (IND) 6-3 6-3; Gavin Van Peperzeel (AUS) beat Kaza Vinayak Sharma (IND) 6-1 6-2; Saketh Myneni (IND) beat Ranjeet Virali Murugesan (IND) (6) 6-3 6-4; Kittiphong Wachiramanowong (THA) (8) beat Ashwin Vijayragavan (IND) 6-3 6-3; Neeraj Elangovan (IND) beat Viju George JR (USA) 6-4 6-1; Vinod Gowda (IND) beat Suraj R Prabodh (IND) 6-2 6-2; Ti-Chen (TPE) (1) beat Shahbaaz Khan (IND) 6-2 6-2; Ajai Selvaraj (IND) beat Saurabh Singh (IND) 6-1 7-6 (3); Vijayant Malik (IND) (3) beat Sebastein Boltz (FRA) 6-3 6-2; Karan Rastogi (IND) (5) beat Warit Sornbutnark (THA) 6-4 6-4; Bowen Ouyang (CHN) beat Scott Puodziunas (AUS) 6-3 7-6(3).