Bihar, Uttar Pradesh and West Bengal, bordering Nepal, were the worst-hit parts of India in the quake measuring 7.9 on the Richter Scale.
Minister of State for Home Kiren Rijiju told PTI that Bihar accounted for the highest number of deaths--38--and 133 people were injured in the state.
In Uttar Pradesh, 11 deaths took place and 69 people were injured while in West Bengal 2 persons perished and 35 were injured in the quake, he said.
The Prime Minister, who took stock of the situation at a high-level meeting here, directed immediate dispatch of rescue and relief teams, including medical staff, to the affected areas.
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He also spoke to Uttar Pradesh Chief Minister Akhilesh Yadav, Bihar Chief Minister Nitish Kumar, West Bengal Chief Minister Mamata Banerjee, Sikkim Chief Minister Pawan Kumar Chamling and Madhya Pradesh Chief Minister Shivraj Singh Chouhan.
The central government's Crisis Management Committee, headed by Cabinet Secretary Ajit Seth, is holding regular meetings to keep a watch on the situation.
"Our focus is on rescue operations. The damage assessment will follow in some time," he said.
Rijiju said rescue and relief teams have been sent to Patna, Supaul, Muzaffarpur, Darbhanga, Gopalganj in Bihar and Gorakhpur in Uttar Pradesh.
Rijiju said that additional personnel of National Disaster Response Force have been sent to quake-hit Bihar, Uttar Pradesh and West Bengal.
He said paramilitary personnel were also put on alert so that they could be deployed at a short notice," he said.
Rijiju said a total of 460 NDRF personnel have been dispatched to Nepal along with all rescue gears to help the local administration in rescue operations.